Primary Identifier | MGI:1316728 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 14852 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable GTPase activity and translation release factor activity. Predicted to be involved in regulation of translational termination and translational termination. Predicted to act upstream of or within protein methylation. Predicted to be located in cytoplasm. Predicted to be part of translation release factor complex. Predicted to be active in cytosolic ribosome. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human GSPT1 (G1 to S phase transition 1). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. In vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture. [provided by MGI curators] |