Primary Identifier | MGI:1921358 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 74108 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including poly(A)-specific ribonuclease activity; protein kinase binding activity; and telomerase RNA binding activity. Acts upstream of or within nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be located in nuclear speck and nucleolus. Predicted to be active in glutamatergic synapse; nucleus; and postsynapse. Is expressed in 2-cell stage embryo; central nervous system; and genitourinary system. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 6. Orthologous to human PARN (poly(A)-specific ribonuclease). PHENOTYPE: Mice homozygous for a null allele die prior to E11.5. [provided by MGI curators] |