| Primary Identifier | MGI:1347522 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 26565 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium-dependent phospholipase A2 activity. Involved in several processes, including cholesterol homeostasis; glycerophospholipid metabolic process; and regulation of lipid transport. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; erythrocyte maturation; and negative regulation of cytokine production involved in inflammatory response. Located in acrosomal vesicle. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human PLA2G10 (phospholipase A2 group X). PHENOTYPE: Mice homozygous for a null allele exhibit decreased lung inflammatory response and TH2 cytokine production in response to chronic ovalbumin exposure and acute asthma models. Mice homozygous for a knock-out allele exhibit decreased injury following myocardial ischemia and reperfusion. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
