| Primary Identifier | MGI:102643 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 17880 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cytoskeletal motor activity. Acts upstream of or within smooth muscle contraction. Located in brush border; smooth muscle contractile fiber; and stress fiber. Part of muscle myosin complex. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and vascular system. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome; patent ductus arteriosus; and thoracic aortic aneurysm. Orthologous to human MYH11 (myosin heavy chain 11). PHENOTYPE: Homozygous null mice have impaired smooth muscle contractility. They are incapable of urinating, exhibit dilative cardiomyopathy, are growth retarded, and die within 3 days of birth. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
