| Primary Identifier | MGI:1096393 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 20583 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and chromatin binding activity. Involved in several processes, including desmosome disassembly; endocardial cushion formation; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Acts upstream of or within with a positive effect on chromatin organization. Acts upstream of or within several processes, including negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of hematopoietic stem cell proliferation; and positive regulation of fat cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Waardenburg syndrome. Human ortholog(s) of this gene implicated in piebaldism. Orthologous to human SNAI2 (snail family transcriptional repressor 2). PHENOTYPE: Mutations in this gene result in growth retardation and eyelid deformities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
