| Primary Identifier | MGI:2441659 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 239739 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in several processes, including negative regulation of proteolysis; regulation of viral life cycle; and response to interferon-alpha. Located in alveolar lamellar body membrane and lysosomal membrane. Is expressed in alveolus epithelium; lung; and lung epithelium. Orthologous to human LAMP3 (lysosomal associated membrane protein 3). PHENOTYPE: Under basal conditions, homozygous null mice display altered protein and lipid composition of pulmonary surfactant but normal viability and lung function. However, under conditions of experimental allergic asthma, mice show increased airway resistance and aggravated changes in BAL lipid composition. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
