| Primary Identifier | MGI:1097705 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 16644 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cysteine-type endopeptidase inhibitor activity; hormone activity; and protease binding activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; negative regulation of blood coagulation; and vasodilation. Located in collagen-containing extracellular matrix. Is expressed in yolk sac. Human ortholog(s) of this gene implicated in hereditary angioedema and high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1). PHENOTYPE: Mice homozygous for a targeted null mutation are viable and grossly unaffected with normal tail vein bleeding times, despite loss of detectable plasma kininogen. However, homozygotes show a significantly longer time to carotid artery occlusion after RoseBengal and laser-induced arterial injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
