| Primary Identifier | MGI:2685452 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 239789 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable chromatin binding activity. Involved in DNA replication. Acts upstream of or within several processes, including cerebrospinal fluid circulation; cilium assembly; and multi-ciliated epithelial cell differentiation. Predicted to be active in nucleus. Is expressed in brain; bronchus; female reproductive system; olfactory epithelium; and respiratory system epithelium. Orthologous to human GMNC (geminin coiled-coil domain containing). PHENOTYPE: Homozygotes for a null allele show postnatal growth retardation and lethality and absent respiratory motile cilia. Homozygotes for a different null allele are runted and show hydrocephaly and infertility due to impaired formation of multiciliated cells in the brain, respiratory tract, and germline. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
