| Primary Identifier | MGI:1096363 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 14729 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables collagen binding activity. Involved in blood coagulation and megakaryocyte development. Acts upstream of or within cell-matrix adhesion and negative regulation of platelet activation. Predicted to be located in cell surface. Predicted to be part of glycoprotein Ib-IX-V complex. Is expressed in several structures, including hepatic primordium; liver; mesenchyme derived from splanchnopleure; placenta; and yolk sac. Orthologous to human GP5 (glycoprotein V platelet). PHENOTYPE: Homozygotes for one null allele develop normally with no spontaneous bleeding while their platelets show normal thrombin responsiveness and lack a Bernard-Soulier phenotype. In contrast, homozygotes for a second null allele show a shorter bleeding time and platelet hyperresponsiveness to thrombin. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
