| Primary Identifier | MGI:2445095 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 224109 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables receptor ligand inhibitor activity and transforming growth factor beta binding activity. Involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta receptor signaling pathway. Located in cell surface and endoplasmic reticulum. Is expressed in brain vascular element; embryo; and thymus primordium. Orthologous to human NRROS (negative regulator of reactive oxygen species). PHENOTYPE: Homozygous knockout leads to increased oxidative stress and susceptibility to experimental autoimmune encephalomyelitis, but to reduced susceptibility to bacterial infections. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
