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Protein Coding Gene : Dynlt2b dynein light chain Tctex-type 2B

Primary Identifier  MGI:1913311 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  66061
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in intraciliary retrograde transport and regulation of intraciliary retrograde transport. Predicted to be located in ciliary base; cytoskeleton; and dynein axonemal particle. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Is expressed in embryo and forelimb bud. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNLT2B (dynein light chain Tctex-type 2B).
PHENOTYPE: Male mice homozygous for a null allele display male infertility with oligoasthenozoospermia, defects in axoneme formation, reduced numbers of elongated spermatids, and defects in sperm flagellum morphology. [provided by MGI curators]
  • synonyms:
  • Tctex1 domain containing 2,
  • Dynlt2b,
  • MGI:1913668,
  • 2410011K15Rik,
  • dynein light chain Tctex-type 2B,
  • RIKEN cDNA 2410011K15 gene,
  • 0610012D17Rik,
  • Tctex1d2,
  • MGI:6458571,
  • RIKEN cDNA 0610012D17 gene

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Mouse features --> Functions (GO terms)

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