| Primary Identifier | MGI:1858308 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 51789 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables WW domain binding activity. Involved in spermatid development. Located in several cellular components, including endosome; growth cone; and neuronal cell body. Is active in postsynaptic cytosol and presynaptic cytosol. Is expressed in several structures, including liver; nervous system; retina; submandibular gland primordium; and vibrissa. Orthologous to human TNK2 (tyrosine kinase non receptor 2). PHENOTYPE: Homozygous null mice exhibit spontaneous activation of CD8+ and CD4+ T cells with T cells showing faster and larger calcium responses, resulting in inhibited growth of transplanted immune checkpoint blockade-resistant prostate tumors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
