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Protein Coding Gene : Itgb5 integrin beta 5
Primary Identifier  MGI:96614 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  16419
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables integrin binding activity. Involved in integrin-mediated signaling pathway; stress fiber assembly; and transforming growth factor beta receptor signaling pathway. Located in cell leading edge and focal adhesion. Part of integrin alphav-beta5 complex. Is active in glutamatergic synapse and synaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Orthologous to human ITGB5 (integrin subunit beta 5).
PHENOTYPE: Homozygotes for a targeted null mutation do not appear to differ from normal in respect to development, reproduction, adenovirus infection, or wound healing. Mutant keratinocytes do show reduced migration on, and adhesion to, vitronectin in vitro. [provided by MGI curators]
  • synonyms:
  • EST AA475909,
  • AA475909,
  • expressed sequence AI874634,
  • integrin beta 5,
  • MGD-MRK-11493,
  • [b]5,
  • [b]-5,
  • ESTM23,
  • beta5,
  • [b]5B,
  • AI874634,
  • Itgb5,
  • MGI:1201382,
  • [b]5A,
  • expressed sequence tag mouse EST 23,
  • MGI:2146516,
  • beta-5
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Interactions

18 Pathways

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Disease

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