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Protein Coding Gene : Cd80 CD80 antigen
Primary Identifier  MGI:101775 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  12519
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable receptor ligand activity. Acts upstream of or within T cell costimulation; cellular response to lipopolysaccharide; and positive regulation of alpha-beta T cell proliferation. Located in external side of plasma membrane. Is expressed in heart ventricle and skin. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CD80 (CD80 molecule).
PHENOTYPE: Homozygous mutation of this gene results in a 70% reduction in the mixed lymphocyte response in LPS- and dextran sulfate-stimulated B cells. [provided by MGI curators]
  • synonyms:
  • Cd28l,
  • lymphocyte antigen 53,
  • CD80 antigen,
  • MGD-MRK-1846,
  • MGD-MRK-12039,
  • B7.1,
  • Cd80,
  • MGD-MRK-18582,
  • B7-1,
  • Ly53,
  • Ly-53,
  • MGD-MRK-11996,
  • CD28 antigen ligand
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Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

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0 Involved In Mutations

0 Strain

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4 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

12 Pathways

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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