Primary Identifier | MGI:2388477 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 207683 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ionotropic glutamate receptor binding activity. Involved in positive regulation of long-term synaptic potentiation; regulation of presynapse assembly; and trans-synaptic signaling. Predicted to be located in excitatory synapse; plasma membrane; and postsynaptic density. Predicted to be active in cell-cell junction. Is expressed in several structures, including adrenal gland; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human IGSF11 (immunoglobulin superfamily member 11). PHENOTYPE: Mice homozygous for a knock-out allele exhibit disrupted synaptic transmission and plasticity. [provided by MGI curators] |