| Primary Identifier | MGI:2443024 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 207798 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cholesterol binding activity and cholesterol transfer activity. Involved in cellular response to cholesterol. Located in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and ventricular layer. Orthologous to human GRAMD1C (GRAM domain containing 1C). PHENOTYPE: Mice homozygous for a knock-out allele are viable and exhibit normal body weight and no significant changes in plasma, liver, or fecal levels of cholesterol and various plant and animal-derived sterols under divergent dietary cholesterol conditions, but do show decreased deoxycholic acid and increased plasma cortisol levels under low dietary cholesterol. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
