| Primary Identifier | MGI:1934368 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 84544 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within negative regulation of natural killer cell cytokine production; negative regulation of type II interferon production; and response to lipopolysaccharide. Predicted to be located in cytoplasm. Is expressed in several structures, including blood; central nervous system; ganglia; heart; and lung. Human ortholog(s) of this gene implicated in C syndrome. Orthologous to human CD96 (CD96 molecule). PHENOTYPE: Mice homozygous for a knock-out allele exhibit hyperinflammatory responses after LPS challenge and increased susceptibility to endotoxin shock but are more resistant to MCA-induced generation of fibrosarcomas or to experimental lung metastases. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
