| Primary Identifier | MGI:1890110 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 268902 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable axon guidance receptor activity and identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and positive regulation of Notch signaling pathway. Acts upstream of or within axon guidance and metanephros development. Located in axolemma. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including autopod; central nervous system; embryo mesenchyme; jaw; and urinary system. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2). PHENOTYPE: Homozygous mutants display postnatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and abnormal commissural axon growth. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
