Primary Identifier | MGI:2136890 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 224440 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables histone H3K4 methyltransferase activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of inflammatory response; and regulation of cell proliferation in bone marrow. Predicted to be located in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human SETD4 (SET domain containing 4). PHENOTYPE: Mice homozygous for a null mutation display reduced expression of inflammatory cytokines by macrophages. [provided by MGI curators] |