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Protein Coding Gene : Chaf1b chromatin assembly factor 1, subunit B

Primary Identifier  MGI:1314881 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  110749
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to be involved in DNA replication-dependent chromatin assembly and nucleosome assembly. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of CAF-1 complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human CHAF1B (chromatin assembly factor 1 subunit B).
PHENOTYPE: Mice homozygous for a conditional allele activated in hematopoietic cells exhibit premature death, pancytopenia, reduced bone amrrow and hematopoietic stem cells, and reduced hematopoietic reconstitution. [provided by MGI curators]
  • synonyms:
  • CAF1A,
  • CAF1P60,
  • 2600017H24Rik,
  • chromatin assembly factor 1, subunit B,
  • expressed sequence C76145,
  • MPHOSPH7,
  • CAF-IP60,
  • RIKEN cDNA 2600017H24 gene,
  • Chaf1b,
  • CAF1,
  • CAF-I 60 kDa subunit,
  • CAF-1 subunit B,
  • MGI:2146692,
  • C76145,
  • MGI:1919322

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11 Involved In Mutations

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