Primary Identifier | MGI:1314881 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 110749 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in DNA replication-dependent chromatin assembly and nucleosome assembly. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of CAF-1 complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human CHAF1B (chromatin assembly factor 1 subunit B). PHENOTYPE: Mice homozygous for a conditional allele activated in hematopoietic cells exhibit premature death, pancytopenia, reduced bone amrrow and hematopoietic stem cells, and reduced hematopoietic reconstitution. [provided by MGI curators] |