Primary Identifier | MGI:1930121 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 114604 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and promoter-specific chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of signal transduction; and regulation of stem cell division. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; incisor; sensory organ; and skin. Orthologous to human PRDM15 (PR/SET domain 15). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic growth retardation and complete midgestation lethality associated with defects in anterior/posterior patterning and forebrain development. [provided by MGI curators] |