| Primary Identifier | MGI:98931 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 22350 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables disordered domain specific binding activity. Involved in several processes, including actin cytoskeleton organization; intestinal D-glucose absorption; and positive regulation of protein localization to plasma membrane. Acts upstream of or within establishment or maintenance of apical/basal cell polarity and receptor internalization. Located in several cellular components, including brush border; microvillus; and uropod. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Orthologous to human EZR (ezrin). PHENOTYPE: Homozygous null mice display postnatal lethality with abnormal intestinal villi morphology. Mice homozygous for a knock-down allele exhibit growth retardation, partial postnatal lethality, achlorhydria, and abnormal gastric parietal cell morphology and response to histamine stimulation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
