| Primary Identifier | MGI:108111 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 20517 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including organic cation transmembrane transporter activity; pyrimidine nucleoside transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including monoamine transport; quaternary ammonium group transport; and spermidine transport. Acts upstream of or within monoatomic cation transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including adrenal gland; liver; mammary gland; metanephros; and nasal cavity mucosa. Orthologous to human SLC22A1 (solute carrier family 22 member 1). PHENOTYPE: Mice homozygous for a knockout allele are viable, healthy, and fertile but exhibit an impaired liver uptake and direct intestinal excretion of substrate organic cations. Mice homozygous for a different knockout allele show alterations in metformin disposition and its glucose-lowering effects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
