| Primary Identifier | MGI:1346875 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 26407 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein kinase activity. Involved in intracellular signal transduction and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including chorionic trophoblast cell differentiation; male germ-line sex determination; and placenta development. Located in cytoplasm. Is expressed in several structures, including central nervous system; future brain; and genitourinary system. Orthologous to human MAP3K4 (mitogen-activated protein kinase kinase kinase 4). PHENOTYPE: Homozygous null mice exhibit some perinatal lethality and survivors appear smaller. On certain genetic backgrounds, heterozygous X/Y mice may develop as phenotypic females or hermaphrodites. The sex-reversal phenotype is dependent on a combination of strain-specific autosomal and Y-linked alleles. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
