| Primary Identifier | MGI:97837 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 19317 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mRNA 3'-UTR binding activity and transcription coactivator activity. Involved in several processes, including negative regulation of metabolic process; regulation of glial cell differentiation; and regulation of mRNA metabolic process. Acts upstream of or within several processes, including long-chain fatty acid biosynthetic process; spermatid development; and vasculature development. Located in cytoplasm and nucleus. Is active in synapse. Is expressed in several structures, including central nervous system; craniocervical region bone; reproductive system; sensory organ; and yolk sac. Orthologous to human QKI (QKI, KH domain containing RNA binding). PHENOTYPE: Knock-out mice die in utero with defects in embryo turning, blood vessel, smooth muscle, cardiac and neural tube development. Homozygotes for a spontaneous allele are viable but show myelin, spermatogenic and behavioral defects, hind leg tremors and seizures. Most ENU-induced mutants die in utero. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
