| Primary Identifier | MGI:1314653 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 17356 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cell adhesion molecule binding activity. Involved in several processes, including cell-cell adhesion mediated by cadherin; pore complex assembly; and regulation of postsynapse assembly. Acts upstream of or within several processes, including adherens junction maintenance; nervous system development; and regulation of oligodendrocyte progenitor proliferation. Located in several cellular components, including adherens junction; apical junction complex; and apical part of cell. Part of pore complex. Is active in hippocampal mossy fiber to CA3 synapse; postsynaptic density membrane; and presynaptic active zone membrane. Is expressed in embryo ectoderm; eye; genitourinary system; nervous system; and tail bud. Orthologous to human AFDN (afadin, adherens junction formation factor). PHENOTYPE: Homozygous null mice display embryonic lethality, abnormal ectoderm development including disrupted cell junctions, and absence of the somites, notochord, allantois, and neural folds. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
