Primary Identifier | MGI:98738 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 21826 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable calcium ion binding activity and heparin binding activity. Involved in negative regulation of angiogenesis. Located in basement membrane. Is expressed in several structures, including central nervous system; genitourinary system; jaw; mesothelium; and musculoskeletal system. Orthologous to human THBS2 (thrombospondin 2). PHENOTYPE: Mice homozygous for a knock-out allele display premature death, abnormal tails, marked structural and functional abnormalities in a variety of connective tissues including skin, tendon, bone, and blood vessels, accelerated wound healing, and enhanced susceptibility to experimental skin tumors. [provided by MGI curators] |