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Protein Coding Gene : Eci1 enoyl-Coenzyme A delta isomerase 1
Primary Identifier  MGI:94871 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  13177
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables delta(3)-delta(2)-enoyl-CoA isomerase activity. Acts upstream of or within fatty acid beta-oxidation. Located in mitochondrial inner membrane. Is expressed in testis. Orthologous to human ECI1 (enoyl-CoA delta isomerase 1).
PHENOTYPE: Mice homozygous for disruption of this gene are normal until stressed. Starvation results in increased accumulation of triglycerides and unsaturated fatty acids in the liver and kidney. Secretion of fatty acid metabolites in the urine is greatly increased. [provided by MGI curators]
  • synonyms:
  • enoyl-Coenzyme A delta isomerase 1,
  • eci,
  • Eci1,
  • dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenyme A isomerase),
  • Dci,
  • MGD-MRK-8810
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