Primary Identifier | MGI:1913461 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 66211 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) A structural constituent of ribosome. Involved in negative regulation of myotube differentiation and regulation of striated muscle tissue development. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2D. Orthologous to human RPL3L (ribosomal protein L3 like). PHENOTYPE: Mice homozygous for a knock-out allele exhibit a reduction in heart weight with age. Another null allele shows reduced cardiac muscle contractility. [provided by MGI curators] |