| Primary Identifier | MGI:1922428 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 75178 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity; single-stranded DNA 3'-5' DNA exonuclease activity; and single-stranded DNA binding activity. Involved in double-strand break repair via homologous recombination; fertilization; and meiosis I. Located in cytoplasm. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in primary ovarian insufficiency and spermatogenic failure 22. Orthologous to human MEIOB (meiosis specific with OB-fold). PHENOTYPE: Mice homozygous for a knock-out allele exhibit male and female infertility associated with germ cell apoptosis, reduced gonads and impaired meiosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
