| Primary Identifier | MGI:894282 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 20609 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable neuropeptide binding activity and somatostatin receptor activity. Acts upstream of or within glucose homeostasis and regulation of insulin secretion. Located in plasma membrane. Is expressed in brain; cochlea; cochlear duct epithelium; cochlear ganglion; and organ of Corti. Human ortholog(s) of this gene implicated in bipolar disorder. Orthologous to human SSTR5 (somatostatin receptor 5). PHENOTYPE: Homozygotes for one null allele display decreased numbers of insulin positive cells in the pancreas. Homozygotes for a second null allele have normal pancreatic islet morphology but increased insulin secretion, decreased blood insulin and glucose levels,and improved glucose tolerance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
