| Primary Identifier | MGI:1096327 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 12005 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including SMAD binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in positive regulation of JNK cascade and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including chordate embryonic development; regulation of macromolecule metabolic process; and regulation of signal transduction. Located in several cellular components, including cell cortex; cytoplasmic vesicle; and microtubule cytoskeleton. Part of Wnt signalosome and beta-catenin destruction complex. Is expressed in several structures, including eye; forebrain; genitourinary system; hemolymphoid system gland; and jaw. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and urinary bladder cancer. Orthologous to human AXIN1 (axin 1). PHENOTYPE: Mutant homozygotes die at embryonic day 8-10, exhibiting neuroectodermal defects and axial duplications. Heterozygotes exhibit skeletal, cardiac, and neurological defects including short, bent tails, and deafness with circling behavior. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
