| Primary Identifier | MGI:106281 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 224647 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of defense response to virus; and negative regulation of protein localization to nucleus. Predicted to act upstream of or within innate immune response. Predicted to be located in centrosome; cytosol; and nuclear speck. Predicted to be active in phagophore assembly site. Is expressed in several structures, including alimentary system; eye; genitourinary system; integumental system; and nervous system. Orthologous to human ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased plasma HDL cholesterol levels due to reduced liver lipoprotein production, decreased circulating LDL cholesterol and phospholipid levels, reduced VLDL-triglyceride secretion, and impaired glucose tolerance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
