| Primary Identifier | MGI:101884 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 19015 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including negative regulation of myoblast differentiation; positive regulation of skeletal muscle tissue regeneration; and regulation of gene expression. Acts upstream of or within several processes, including keratinocyte migration; keratinocyte proliferation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in chromatin and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and sensory organ. Used to study Huntington's disease and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). PHENOTYPE: Mice homozygous for a number of different targeted mutations show variable prenatal lethality and a range of phenotypes such as placental, brain, skin, hair follicle, adipose and lipid homeostasis abnormalities, growth retardation, reduced fertility, andincreased incidence of tumors/induced tumors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
