Primary Identifier | MGI:1343877 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 19896 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in several structures, including cerebral cortex; heart; immune system; liver; and lung. Orthologous to human RPL10A (ribosomal protein L10a). PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality prior to E9.5. Mice homozygous for a hypomorphic allele exhibit perinatal lethality, abnormal brain morphology, edema, ectopic blood vessels, caudal body truncation, short rostral-caudal axis, abnormal somites, oligodactyly, and altered respiratory cilium basal feet orientation. [provided by MGI curators] |