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Protein Coding Gene : Cmtr1 cap methyltransferase 1

Primary Identifier  MGI:1921407 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  74157
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable mRNA (nucleoside-2'-O-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; olfactory epithelium; and retina. Orthologous to human CMTR1 (cap methyltransferase 1).
PHENOTYPE: Homozygous knockout is early embryonic lethal. Conditional homozygous KO in neurons leads to reduced neocortex size and neurite dysmorphology. [provided by MGI curators]
  • synonyms:
  • Ftsjd2,
  • 1300018I05Rik,
  • expressed sequence AI451264,
  • RIKEN cDNA 1300018I05 gene,
  • AI451264,
  • FtsJ methyltransferase domain containing 2,
  • MGI:2146866,
  • Cmtr1,
  • cap methyltransferase 1

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