Primary Identifier | MGI:1921407 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 74157 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable mRNA (nucleoside-2'-O-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; olfactory epithelium; and retina. Orthologous to human CMTR1 (cap methyltransferase 1). PHENOTYPE: Homozygous knockout is early embryonic lethal. Conditional homozygous KO in neurons leads to reduced neocortex size and neurite dysmorphology. [provided by MGI curators] |