| Primary Identifier | MGI:95742 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 109801 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables lactoylglutathione lyase activity and zinc ion binding activity. Involved in osteoclast differentiation. Acts upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). PHENOTYPE: Mice homozygous for a knock-out allele show accumulation of a methylglyoxal-derived advanced glycation end product in liver and alterations in anxiety- and depression-like behaviors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
