| Primary Identifier | MGI:88135 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 21784 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable growth factor activity. Acts upstream of or within cell differentiation and negative regulation of cell population proliferation. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; ear; nervous system; reproductive system; and skeleton. Used to study stomach cancer. Orthologous to human TFF1 (trefoil factor 1). PHENOTYPE: Mice homozygous for a knockout allele exhibit small intestine and gastric mucosa abnormalities and develop antropyloric adenomas with full penetrance; one-third of homozygotes develop multifocal intraepithelial or intramucosal carcinomas. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
