| Primary Identifier | MGI:1889002 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 57773 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable tRNA methyltransferase activator activity. Predicted to be involved in tRNA (guanine-N7)-methylation. Predicted to be located in nucleoplasm. Predicted to be part of tRNA (m7G46) methyltransferase complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and thymus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and microcephaly, growth deficiency, seizures, and brain malformations. Orthologous to human WDR4 (WD repeat domain 4). PHENOTYPE: Mice homozygous for a null allele display lethality during organogenesis with increased apoptosis and DNA damage. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
