Primary Identifier | MGI:98884 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 108121 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RS domain binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nuclear speck. Is expressed in several structures, including central nervous system; genitourinary system; peripheral nervous system; sensory organ; and skeleton. Orthologous to human U2AF1 (U2 small nuclear RNA auxiliary factor 1). PHENOTYPE: Mice homozygous for a conditional allele activated upon induction with pIpC exhibit impaired hematopoietic stem cell survival and function. [provided by MGI curators] |