| Primary Identifier | MGI:1925915 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 224703 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ubiquitin protein ligase activity. Involved in antibacterial innate immune response and antiviral innate immune response. Predicted to be located in several cellular components, including Golgi membrane; cytosol; and endoplasmic reticulum. Is expressed in several structures, including axial skeleton; bone; hemolymphoid system gland; nervous system; and sensory organ. Orthologous to human MARCHF2 (membrane associated ring-CH-type finger 2). PHENOTYPE: Mice homozygous for a null allele exhibit resistance to bacterial and viral infection with reduced bacterial or viral load and increased cytokine production in addition to increased lethality induced by LPS treatment. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
