| Primary Identifier | MGI:1197015 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 13163 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables histone binding activity and transcription coactivator activity. Involved in several processes, including nucleosome assembly; positive regulation of transcription by RNA polymerase II; and protein localization to chromatin. Acts upstream of or within several processes, including apoptotic signaling pathway; negative regulation of DNA-templated transcription; and regulation of apoptotic process. Located in PML body and cytosol. Colocalizes with heterochromatin. Is expressed in several structures, including early embryo; genitourinary system; heart; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in appendiceal neoplasm; islet cell tumor; oral squamous cell carcinoma; ovary epithelial cancer; and pancreatic endocrine carcinoma. Orthologous to human DAXX (death domain associated protein). PHENOTYPE: Mice homozygous for a targeted mutation of this gene display extensive apoptosis and embryonic lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
