Primary Identifier | MGI:1101770 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 19763 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity and ubiquitin-protein transferase activator activity. Acts upstream of or within with a positive effect on chromatin organization. Acts upstream of or within anterior/posterior pattern specification; camera-type eye morphogenesis; and negative regulation of DNA-templated transcription. Located in nuclear body and sex chromatin. Part of PRC1 complex. Is expressed in several structures, including central nervous system; hemolymphoid system gland; liver; reproductive system; and urinary system. Orthologous to human RING1 (ring finger protein 1). PHENOTYPE: Both homozygous and heterozygous mutant mice show axial skeleton defects including anterior transformations of vertebrae and rib abnormalities. [provided by MGI curators] |