| Primary Identifier | MGI:95921 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 14998 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Involved in positive regulation of germinal center formation and positive regulation of humoral immune response. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; chaperone cofactor-dependent protein refolding; and positive thymic T cell selection. Located in endosome membrane; lysosomal membrane; and multivesicular body. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human HLA-DMA (major histocompatibility complex, class II, DM alpha). PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired antigen presenting cell function, poor IgG responses to T-dependent antigens, reduced numbers of mature CD4+ T cells, and increased susceptibility to Leishmania major infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
