| Primary Identifier | MGI:95925 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 15002 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of antigen processing and presentation of peptide antigen via MHC class II; and peptide antigen assembly with MHC class II protein complex. Predicted to be located in lysosome. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Is expressed in hemolymphoid system and metanephros. Orthologous to human HLA-DOB (major histocompatibility complex, class II, DO beta). PHENOTYPE: Homozygous loss-of-function mutations in this gene result in defective assembly of class II molecules, decreased susceptibility to viral infection, and decreased incidence of MMTV-induced mammary tumors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
