| Primary Identifier | MGI:95900 | Organism | mouse, laboratory |
| Chromosome | 17 | Mgi Type | polymorphic pseudogene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including MHC class II protein complex binding activity; T cell receptor binding activity; and peptide antigen binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II; immunoglobulin mediated immune response; and positive regulation of immune response. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in Parkinson's disease (multiple); allergic disease; asthma; and autoimmune disease (multiple). Orthologous to human HLA-DRA (major histocompatibility complex, class II, DR alpha). |
| specificity | The differential expression of H2-Ea is caused by a loss-of-function deletion of about 600 bp in the promoter and first exon of the H2-Ea gene that occurs in strains of the H2b but not in H2k or H2d haplotype (Jones PP, Murphy DB, McDevitt HO Variable synthesis and expression of E alpha and Ae (E beta) Ia polypeptide chains in mice of different H-2 haplotypes. Immunogenetics 1981;12:321-37.) C57BL/6, C57BL/10, C57L/J, LP/J, and 129 mice are among the strains that carry H2<sup>b</sup> and have a deletion of part of H2-Ea. A/He, A/J carry H2<sup>a</sup> and DBA/2, NZB, C57BL/KsJ, and BALB/c mice carry H2<sup>d</sup>. CBA/J, MA/My, AKR, C57BR/cdJ, RF/J, C58/J, and C3H(C3H/He, C3HeB/FeJ) mice carry H2<sup>k</sup>. These strains and others have an intact H2-Ea gene. |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
