| Primary Identifier | MGI:96244 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 193740 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein folding chaperone. Involved in lysosomal transport and protein folding. Acts upstream of or within DNA repair; response to heat; and telomere maintenance. Located in cytoplasm. Is expressed in several structures, including adrenal gland; crista ampullaris; early conceptus; genitourinary system; and vibrissa. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to human HSPA1A (heat shock protein family A (Hsp70) member 1A) and HSPA1B (heat shock protein family A (Hsp70) member 1B). PHENOTYPE: At the cellular level, mice homozygous for a knock-out allele exhibit impaired thermotolerance and increased sensitivity to heat stress-induced apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
