| Primary Identifier | MGI:1329021 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 17687 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable double-stranded DNA binding activity. Acts upstream of or within female gamete generation and homologous chromosome pairing at meiosis. Located in synaptonemal complex. Is expressed in several structures, including heart; liver; lung; spleen; and testis. Used to study primary ovarian insufficiency 13. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; primary ovarian insufficiency 13; and spermatogenic failure 74. Orthologous to human MSH5 (mutS homolog 5). PHENOTYPE: Homozygotes for targeted null mutations exhibit disrupted chromosome pairing in meiosis I resulting in cell death and sterility. In males, testes size is reduced, and in females, there is a total loss of ovarian structure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
