| Primary Identifier | MGI:1913869 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 73242 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables tubulin N-acetyltransferase activity. Involved in microtubule cytoskeleton organization; response to mechanical stimulus; and response to pain. Acts upstream of or within several processes, including alpha-tubulin acetylation; dentate gyrus development; and positive regulation of NLRP3 inflammasome complex assembly. Located in microtubule bundle. Is active in membrane. Is expressed in several structures, including adrenal gland; central nervous system; gut; male reproductive gland or organ; and neural retina. Orthologous to human ATAT1 (alpha tubulin acetyltransferase 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired alpha tubulin acetylation and abnormal dentate gyrus morphology. Mice homozygous for a different knock-out allele exhibit reduced male fertility associated with teratozoospermia, oligozoospermia andasthenozoospermia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
