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Protein Coding Gene : Trim31 tripartite motif-containing 31
Primary Identifier  MGI:2385051 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  224762
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables ubiquitin protein ligase activity. Involved in several processes, including antiviral innate immune response; negative regulation of NLRP3 inflammasome complex assembly; and protein K48-linked ubiquitination. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in Peyer's patch; gut; and testis. Orthologous to human TRIM31 (tripartite motif containing 31).
PHENOTYPE: Homozygous knockout exacerbates the immune response after induced inflammation and in induced peritonitis and reduces the immune response in induced colitis. [provided by MGI curators]
  • synonyms:
  • cDNA sequence BC026666,
  • MGC:37625,
  • tripartite motif-containing 31,
  • HCG1,
  • Trim31,
  • BC026666
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